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APA Handbook of Depression Arie Y. Lewin The authors put forward aDepression is a leading cause of disability, a major contributor to global disease burden, and one of the most commonly presenting problems in mental health and primary care settings. Its pervasive impact on individuals, families, and communities underscores the urgency of advancing understanding and treatment of this complex mental health condition. The APA Handbook of Depression reflects the critical need for a comprehensive resource that highlights